Researchers Pinpoint Array of Obesity Genes

[Elmore Furth]

Scientists have known for a long time that there seems to be a genetic basis for the tendency toward obesity. Here is a report that summarizes that latest genetic loci and gene variant effects.

So I'm not big boned, it's just genetic in my case. Don't judge me.

In one report, researchers say they have identified 18 gene variants linked to obesity and confirmed the involvement of 14 others. In a second report, the same group of researchers say they have identified 13 gene variants that appear to direct fat to the belly or thighs. . . Among these genes, seven had a stronger effect on women than men.

In this meta-analysis, which is a review of previously published studies, Loos' group was able to find 18 new genomic regions associated with BMI, and confirm 14 regions that had been identified before.

Loos noted that the more of the gene variants a person has, the greater their susceptibility to obesity. These variants are inherited from both your mother and your father, so you can have as many as 64 variants, she explained.

The average person has about 28 to 32 of these variants; about 2 percent of the population carries more than 38 variants and 2 percent of the population carries less than 21, Loos added.

Researchers Pinpoint Array of Obesity Genes