Living with my dementia

[Omaha Steve]

42. Trazodone is primarily used for the following conditions:

Technically, I use it for sleep.

Depression: Trazodone is used to treat major depressive disorder and can be prescribed alone or in combination with other antidepressants.

Insomnia: It is commonly used off-label for sleep difficulties, especially when insomnia is linked to depression.

Anxiety: Trazodone can help relieve symptoms of anxiety.

Other conditions: It may be used for other off-label purposes as determined by a doctor.

It was research in England that pointed to it slowing down FTD.

ALSO https://psychiatryonline.org/doi/10.1176/appi.neuropsych.21060166

Trazodone.
Trazodone has been effective in treating agitation and aggression in FTD and may also function as a sleep aid, if necessary (82). In one study, it was also found that trazodone can reduce the behavioral symptoms of FTD that were assessed by the NPI score, especially eating disorder, irritability, agitation, and depressive symptoms (95).

Further down: FTD treatment has been limited to the management of neuropsychiatric symptoms, these being the most prominent feature of the disease. Therapeutic strategies have focused on nonpharmacological interventions such as behavioral and environmental manipulation, caregiver interventions, and speech therapy for the language variants of FTD. Also, pharmacological treatment has also been used to treat these symptoms, with variable but sometimes positive results. With the advance of knowledge regarding the pathophysiology of FTD, pharmacological interventions such as the use of SSRIs, trazodone, or second-generation antipsychotics have a solid scientific basis for the treatment of FTD.

In the past 10 years, thanks to new techniques in neuroimaging, genetics, and biomarker analysis, much has been discovered about the phenomena underlying frontotemporal lobar degeneration. This has allowed the design of new molecule-based therapies that are still in the early stages of research but show promising results.