A New 'Nanoparticle Vaccine' Prevented Cancer In Mice, Study Says
Source: 404 Media
Scientists have developed a unique nanoparticle vaccine that prevented the development of multiple forms of cancer in mice, reports a study published in Cell Reports Medicine on Thursday.
Eighty percent of mice that received the novel vaccine and were subsequently exposed to cancerous cells did not develop tumors and survived to the end of the 250-day long experiment. In contrast, all of the mice that received different vaccine formulations, or remained unvaccinated, developed tumors and none survived longer than 35 days.
It’s too early to know if this breakthrough will ever be applicable to human cancer prevention or treatment, but the successful demonstration in mice is a promising result for the team’s so-called “super-adjuvant” vaccine. This approach uses nanoparticles made of fatty molecules to deliver two distinct “adjuvants,” which are substances in vaccines that enhance an immune response.
“The results that we have are super exciting, and we're really looking forward to pushing forward to the next steps,” said Griffin Kane, a postdoctoral research associate at the University of Massachusetts Amherst and first author on the paper, in a call with 404 Media. “But I think that the translation of these types of therapies from preclinical mouse models to the clinic is a very humbling experience for a lot of people and teams.”
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Read more: https://www.404media.co/a-new-nanoparticle-vaccine-prevented-cancer-in-mice-study-says/
The link 404 Media gives for the study - https://dx.doi.org/10.1016/j.xcrm.2025.102415 is the link they give at this time - just gets you an error message. I hope they'll correct it.
Here's the correct link for the study in Cell Reports Medicine: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00488-4 --- HOWEVER, since DU's software breaks the link at the parentheses, just copy the complete link
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00488-4
into the address bar.
I found that address for the study in this article from the University of Massachusetts Amherst:
https://www.umass.edu/news/article/umass-amherst-researchers-create-nanoparticle-vaccine-prevents-cancer-mice
UMass Amherst Researchers Create Nanoparticle Vaccine That Prevents Cancer in Mice
The vaccine also proves highly effective at preventing cancer’s deadly spread
October 9, 2025
A study led by University of Massachusetts Amherst researchers demonstrates that their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice. Not only did up to 88% of the vaccinated mice remain tumor-free (depending on the cancer), but the vaccine reduced—and in some cases completely prevented—the cancer’s spread.
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The first test paired her nanoparticle system with well-characterized melanoma peptides (called an antigen, similar to how a flu shot typically contains parts of the inactivated flu virus). The formulation activated immune cells called T cells, priming them to recognize and attack this type of cancer. Three weeks later, the mice were exposed to melanoma cells.
Eighty percent of these “super adjuvant” vaccinated mice remained tumor-free and survived until the completion of the study (250 days). In comparison, all of the mice vaccinated with traditional vaccine systems, non-nanoparticle formulations or unvaccinated mice developed tumors; none survived longer than 35 days.
The vaccine also protected against the spread of cancer to the lungs. When exposed to melanoma cells systemically, which mimics how cancer metastasizes, none of the nanoparticle-vaccinated mice developed lung tumors, while all of the other mice did.
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= new reply since forum marked as read
They'll work their way into every one that way lol
